• 

  塗聖賢

  意昂4平台特聘教授🤽🏻，博士生導師，意昂4体育平台生物醫療儀器縱主任🛋，生物醫學儀器研究所心血管創新器械與智能計算實驗室主任，意昂4平台-博動醫學影像技術聯合實驗室主任，荷蘭Erasmus大學醫意昂4客座教授。主要從事心血管成像及生理功能學評估技術的研發與臨床應用研究。2012年2月獲得荷蘭萊頓大學優秀博士學位🫷🏼，2014年回國加入意昂4体育平台陳亞珠院士研究團隊💴，創建心血管影像研究方向👷🏽‍♀️。他發明了QFR、OFR、UFR與RWS等序列計算冠脈功能學評估技術，並主持完成這些技術的產學研與臨床轉化😤。近5年以第一作者或通訊作者（含共同）在Lancet, Nature Review Cardiology, JACC, European Heart Journal等國際知名期刊發表多篇論文。主持的項目“Real-time comprehensive assessment of coronary physiology and biomechanics from a single angiographic projection”獲得2022年EuroPCR大會評選的心血管器械最佳創新獎與Jon DeHaan基金會獎金，成為該獎項設立以來首個獲得殊榮的來自亞洲的項目。擔任The International Journal of Cardiovascular Imaging期刊副主編😙，JACC: Asia期刊欄目編輯，Lancet、JACC、European Heart Journal等二十種國際期刊的審稿專家😴，TCT與EuroPCR等多個心血管介入臨床大會的Faculty/主席團成員🦸🏿‍♀️。獲得2022年度上海市技術發明獎一等獎、2019年度教育部長江學者特聘教授、2019年度上海市優秀技術帶頭人，第四屆轉化醫學創新獎等榮譽稱號。

  E-mail: sxtu@sjtu.edu.cn

  電話：021-62932631

  
  

  
  

  
  

國家自然科學基金委重大科研儀器研製項目，項目名稱：血管內多模態成像與生物力學分析融合系統的研製；項目編號：82327808🫵🏻；時間：2024/1-2028/12。主持👩‍❤️‍💋‍👩。

國家自然科學基金重點國際合作項目，項目名稱：影響冠心病患者生物可降解支架療效的關鍵生物力學問題研究🈂️；項目編號：82020108015；時間：2021/1-2025/12👩🏿‍🦲。主持👨🏽‍🎤。

國家自然科學基金面上項目，項目名稱🦴：冠心病患者非靶病變快速進展與斑塊破裂的生物力學機製研究⚱️◻️；項目編號：81871460；時間：2019/1-2022/12🪟。主持。

國家自然科學基金面上項目，項目名稱：結合計算流體力學與三維光學相幹斷層成像評價冠心病支架治療後的局部血流動力學；項目編號🚵🏿‍♀️：81570456；時間：2016/1-2017/12♡。 主持。

國家自然科學基金青年科學基金項目😽，項目名稱：基於冠狀動脈CT血管造影評估血流儲備分數與微循環阻力；項目編號🧞‍♀️：31500797；時間🗳：2016/1-2018/12。主持。



國家重點研發計劃“科技助力經濟2020”重點專項，項目名稱：融合光學血流分數與虛擬組織學的一站式冠心病評估系統研發和應用示範🤦🏿‍♂️；時間：2020/7-2022/6❇️🤒。主持🧏🏻。

國家重點研發計劃“數字診療裝備研發重點專項”🍎🐹，項目名稱〽️：融合光學相幹斷層成像與血流動力學的一站式冠心病評估系統的研製👮🏿；項目編號：2016YFC0100500；時間👨🏼‍🎓：2016/7-2018/12🐖。主持🏃。

• • Chen Y, Li G*, Li C, Yu W, Fan Z, Bai J, Tu S*. GVM-Net: A GNN-Based Vessel Matching Network for 2D/3D Non-Rigid Coronary Artery Registration. IEEE Trans Med Imaging. Epub ahead of print, DOI: 10.1109/TMI.2025.3540906.
  • Yang F, Li C, Tan Q, Yu W, De Maria GL, Wang F, Wu J*, Tu S*. In Vivo Quantitative Imaging of Coronary Blood Flow by Intracoronary Doppler OCT. IEEE Trans Biomed Eng. Epub ahead of print, DOI: 10.1109/TBME.2024.3517542. 
  • Li C, Qiao Y, Yu W, Li Y, Chen Y, Fan Z, Wei R, Yang B, Wang Z, Lu X, Chen L, Collet C, Chu M*, Tu S*. AutoFOX: An automated cross-modal 3D fusion framework of coronary X-ray angiography and OCT. Medical Image Analysis 2025,101:103432.[view]
    
  • Li Z, Tu S*, Matheson MB, Li G, Chen Y, Rochitte CE, Chen MY, Dewey M, Miller JM, R. Scarpa Matuck B, Yang W, Qin L, Yan F, Lima JaC, Arbab-Zadeh A, De Roos A, Wolfe S. Prognostic Value of Coronary CT Angiography–Derived Quantitative Flow Ratio in Suspected Coronary Artery Disease. Radiology. 2024,313(3):e240299.[view]
  • Huang X, Gao L, Ge W, Li S, Liu Y, Fan X*, Tu S*, Wang F*. An ultrasound-activated piezoelectric sonosensitizer enhances mitochondrial depolarization for effective treatment of orthotopic glioma. Acta Biomater. 2024.[view]
  • Li G, Weng T, Sun P, Li Z, Ding D, Guan S, Han W, Gan Q, Li M, Qi L, Li C, Chen Y, Zhang L, Li T, Chang X, Daemen J, Qu X*, Tu S*. Diagnostic performance of fully automatic coronary CT angiography-based quantitative flow ratio. Journal of Cardiovascular Computed Tomography. 2024.[view]
  • Chu M, De Maria G*, Dai R, Benenati S, Yu W, Zhong J, Kotronias R, Walsh J, Andreaggi S, Zuccarelli V, Chai J, Oxford Acute Myocardial Infarction (OxAMI) Study, Channon K, Banning A, Tu S*. DCCAT: Dual-Coordinate Cross-Attention Transformer for thrombus segmentation on coronary OCT. Medical Image Analysis. 2024, 97: p103265. [view]
  • Fezzi S, Ding D, Mahfoud F, Huang J, Lansky AJ, Tu S*, Wijns W*. Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention? Nature Reviews Cardiology. 2024. DOI: 10.1038/s41569-024-01014-0 [view]
  • Yang S, Wang Z, Park S, Hong H, Li C, Liu X, Chen L, Hwang D, Zhang J, Hoshino M, Yonetsu T, Shin E, Doh J, Nam C, Wang J, Chen S, Tanaka N, Matsuo H, Kubo T, Chang H, Kakuta T, Koo B*, Tu S*. Relationship of Coronary Angiography-Derived Radial Wall Strain With Functional Significance, Plaque Morphology, and Clinical Outcomes. J Am Coll Cardiol Interv 2024; 17(1): 46-56. [view]
  • Tu S*, Xu B*, Chen L, Hong H, Wang Z, Li C, Chu M, Song L, Guan C, Yu B, Jin Z, Fu G, Liu X, Yang J, Chen Y, Ge J, Qiao S, Wijns W, on behalf of the FAVOR III China study group. Short-term risk stratification of non–flow-limiting coronary stenosis by angiographically derived radial wall strain. J Am Coll Cardiol. 2023, 81(8):756–767. [view] 
  • Li C, Wang Z, Yang H, Hong H, Li C, Xu R, Wu Y, Zhang F, Qian J, Chen L, Tu S*, Ge J*. The Association Between Angiographically Derived Radial Wall Strain and the Risk of Acute Myocardial Infarction. J Am Coll Cardiol Interv 2023,16(9):1039-1049. [view]
  • Chu M, Wu P, Li G, Yang W, Gutiérrez-Chico JL, Tu S*. Advances in Diagnosis, Therapy, and Prognosis of Coronary Artery Disease Powered by Deep Learning Algorithms. JACC: Asia 2023; 3(1):1-14. [view]
  • Hong H#, Li C#, Gutiérrez-Chico JL, Wang Z, Huang J, Chu M, Kubo T, Chen L*, Wijns W, Tu S*.  Radial wall strain: a novel angiographic measure of plaque composition and vulnerability. EuroIntervention 2022;18(12):1001-1010. [view]
  • Song L, Xu B, Tu S, Guan C, Jin Z, Yu B, Fu G, Zhou Y, Wang J, Chen Y, Pu J, Chen L, Qu X, Yang J, Liu X, Guo L, Shen C, Zhang Y, Qi Zhang, Pan H, Zhang R, Liu J, Zhao Y, Wang Y, Dou K, Kirtane A, Wu Y, Wijns W, Yang W, Leon M, Qiao S, Stone G, FAVOR III China Study Group. 2-Year Outcomes of Angiographic Quantitative Flow Ratio-Guided Coronary Interventions. J Am Coll Cardiol 2022; 80(22):2089-2101. [view]
  • Wang Z, Xu B, Li C, Guan C, Chang Y, Xie L, Zhang S, Huang J, Serruys PW, Wijns W, Chen L*, Tu S*. Angiography-derived radial wall strain predicts coronary lesion progression in non-culprit intermediate stenosis. J Geriatr Cardiol 2022;19(12):937-948.[view]
  • Hong H#, Jia H#, Zeng M, Gutiérrez-Chico JL, Wang Y, Zeng X, Qin Y, Zhao C, Chu M, Huang J, Liu L, Hu S, He L, Chen L, Wijns W, Yu B*, Tu S*. Risk Stratification in Acute Coronary Syndrome by Comprehensive Morphofunctional Assessment With Optical Coherence Tomography. JACC: Asia 2022; 4: 460-472. [view]
  • Xu B.#*, Tu S.#, Song L.#, Jin Z., Yu B., Fu G., Zhou Y., Wang J. a., Chen Y., Pu J., Chen L., Qu X., Yang J., Liu X., Guo L., Shen C., Zhang Y., Zhang Q., Pan H., Fu X., Liu J., Zhao Y., Escaned J., Wang Y., Fearon W. F., Dou K., Kirtane A. J., Wu Y., Serruys P. W., Yang W., Wijns W., Guan C., Leon M. B., Qiao S., Stone G. W. Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial. The Lancet 2021; 398：2149-2159. [view] 
  • Ding D, Huang J, Westra J, Cohen D. J, Chen Y, Andersen B. K, Holm N. R, Xu B, Tu S*, Wijns W*. Immediate post-procedural functional assessment of percutaneous coronary intervention: current evidence and future directions. Eur Heart J 2021; 42:2695-2707. [view]
  • Chu M, Jia H, Gutiérrez-Chico JL, Maehara A, Ali Z, Zeng Z, He L, Zhao C, Matsumura M, Wu P, Zeng M, Kubo T, Xu B, Chen L, Yu B, Mintz GS, Wijns W, Holm NR, Tu S*. Artificial intelligence and optical coherence tomography for the automatic characterisation of human atherosclerotic plaques.  EuroIntervention 2021; 17:41-50. [view]
  • Yu W, Tanigaki T, Ding D, Wu P, Du H, Ling Li, Huang B, Li G, Yang W, Zhang S, Yan F, Okubo M, Xu B, Matsuo H, Wijns W, Tu S*. Accuracy of Intravascular Ultrasound-based Fractional Flow Reserve in Identifying Hemodynamic Significance of Coronary Stenosis. Circ Cardiovasc Interv. 2021;14:e009840. [view]
  • Tu S*, Ding D, Chang Y, Li C, Wijns W, Xu B.  Diagnostic accuracy of quantitative flow ratio for assessment of coronary stenosis significance from a single angiographic view: A novel method based on bifurcation fractal law. Catheter Cardiovasc Interv 2021;97 Suppl 2:1040-1047.  [view]
  • Tu S^#*, Westra J^#, Adjedj J^#, Ding D, Liang F, Xu B, Holm NR, Reiber H, Wijns W. Fractional Flow Reserve in clinical practice: from wire-based invasive measurement to image-based computation. Eur Heart J 2020; 41, 3271–3279. [view]
  • Yu W, Huang H, Jia D, Chen S, Raffel OC, Ding D, Tian F, Kan J, Zhang S, Yan Y, Chen Y, Bezerra HG, Wijns W, Tu S*. Diagnostic Accuracy of Intracoronary Optical Coherence Tomography-derived Fractional Flow Reserve for Assessment of Coronary Stenosis Severity. EuroIntervention 2019;15:189-197.[view]
  • Xu B^#, Tu S^#*, Qiao S, Qu X, Chen Y, Yang J, Guo L, Sun Z, Li Z, Tian F, Fang W, Chen J, Li W, Guan C, Holm NR, Wijns W, Hu S*. Diagnostic Accuracy of the Angiography-Based Quantitative Flow Ratio for Online Assessment of Coronary Stenosis. J Am Coll Cardio 2017; 70: 3077-87.[view]
  • Tu S*, Westra J, Yang J, von Birgelen C, Ferrara A, Pellicano M, Nef H, Tebaldi M, Murasato Y, Lansky A, Barbato E, van der Heijden LC, Reiber JHC, Holm NR, Wijns W,FAVOR Pilot Trial Study Group. Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography: The International Multicenter FAVOR Pilot Study. J Am Coll Cardiol Interv 2016; 9:2024–35. [view]
  • Li Y, Gutiérrez-Chico JL, Holm NR, Yang W, Hebsgaard L, Christiansen EH, Mæng M, Lassen JF, Yan F, Reiber JHC, Tu S*. Impact of Side Branch Modeling on Computation of Endothelial Shear Stress in Coronary Artery Disease: Coronary Tree Reconstruction by Fusion of 3D Angiography and OCT. J Am Coll Cardio 2015; 66:125-35. [view]
  • Tu S*, Barbato E, Koszegi Z, Yang J, Sun Z, Holm NR, Tar B, Li Y, Rusinaru D, Wijns W, Reiber JHC.Fractional flow reserve calculation from 3-dimensional quantitative coronary angiography and TIMIframe count: A fast computer model to quantify the functional significance of moderately obstructed coronary arteries. J Am CollCardiolInterv 2014, 7:768-777.[view]