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  夏偉梁

  夏偉梁，意昂4平台長聘正教授，博士生導師🔠，溥淵未來技術意昂4副院長, 腫瘤系統醫學全國重點實驗室兼職課題組長🫚。曾於清華大學🦶🏼、香港大學🐖、美國洛克菲勒大學及加州大學舊金山分校學習和深造🕒。入選上海市科委啟明星👨‍🌾、上海交大晨星學者、唐立新優秀學者🤭，獲教育部“基礎學科拔尖學生培養計劃2.0”榮譽獎項-優秀管理人員獎、中華醫學科技獎二等獎、意昂4平台教書育人集體獎二等獎及教學成果獎特等獎等榮譽🏷。任中國生物醫學工程學會、中國細胞生物學學會、美國癌症研究協會會員；Extracellular Vesicles and Circulating Nucleic Acids(EVCNA) 副主編🥷🏿，Frontiers in Oncology-Molecular and Cellular Oncology， Associate Editor。曾任中國細胞生物學學會第二屆青年工作委員會委員🚅🦁、意昂4平台學術委員會委員（2016-2020年）。

   

  立足醫工交叉⚪️，聚焦肺癌等難治疾病的機製和診療新靶點，研究FGF/FGFR等生長因子信號促進肺癌進展和外泌體生物學及診療應用☢️。主持科技部973課題、國家自然科學基金委、醫工交叉重點等基金十余項。在Science Translational Medicine, Cell Death & Differentiation、PNAS、Oncogene↔️👩🏽‍🔧、Protein Cell、 Biomaterials等發表約130余篇學術論文，H-因子50。

腫瘤進展、治療抵抗的機製及新靶點發現（Mechanisms of lung/prostate cancer progression and treatment resistance, and discovery of novel targets）; 外泌體生物學及其應用（biology of exosome and applications）; FGF/FGFR和Sirtuin在腫瘤和組織修復的作用（role of FGF/FGFR and sirtuin in cancer and tissue repair）。

1.       Chen Z, Ji W, Feng W, Cui J, Wang Y, Li F, Chen J, Guo Z, Xia L, Zhu X, Niu X, Zhang Y, Li Z, Wong AS, Lu S*, Xia W*. PTPRT loss enhances anti-PD-1 therapy efficacy by regulation of STING pathway in non-small cell lung cancer. Sci Transl Med. 2024 Sep 4;16(763):eadl3598. doi: 10.1126/scitranslmed.adl3598.

2.       Wu T, Zhang Y, Han Q, Lu X, Cheng Y, Chen J, Sha J, Xia W*. Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression. Oncogene. 2023;42:2801-2815.

3.       Zhang Y, Wu T, Wang Y, Chen Z, Chen J, Lu S, Xia W*. Reciprocal FGF19-GLI2 signaling induces epithelial-to-mesenchymal transition to promote lung squamous cell carcinoma metastasis. Cell Oncol. 2023;46:437-450.

4.       Tian A, Wu T, Zhang Y, Chen J, Sha J, Xia W*. Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer. Cell Oncol. 2023;46:1855-1870.

5.       Lu X, Han Q, Chen J, Wu T, Cheng Y, Li F, Xia W*. Celery (Apium graveolens L.) Exosome-like Nanovesicles as a New-Generation Chemotherapy Drug Delivery Platform against Tumor Proliferation. J Agri Food Chem. 2023; 71:8413-8424.

6.       Cheng Y, Lu X, Li F, Chen Z, Zhang Y, Han Q, Zeng Q, Wu T, Li Z, Lu S, Williams C, Xia W*. NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation. Protein Cell. 2023;14:123-136.

7.       Han Q, Xie QR, Li F, Cheng Y, Wu T, Zhang Y, Lu X, Wong AST, Sha J*, Xia W*. Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer. Theranostics. 2021;11:6526-6541.

8.       Yang X, Zhang Y, Geng K, Yang K, Shao J, Xia W*. Sirt3 protects against ischemic stroke injury by regulating HIF-1α/VEGF signaling and blood–brain barrier integrity. Cell Mol Neurobiol. 2021;41: 1203-1215.

9.       Li F, Li Z, Han Q, Chen Y, Ji W, Yang Y, Lu S, Xia W*. Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104. Oncogene. 2020; 37:3507–3521.

10.    Cheng Y, Zeng Q, Han Q, Xia W*. Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes. Protein Cell. 2019; 10:295-299.

11.    Liu J, Liu Y, Shao J, Li Y, Qin L, Shen H, Xie Y, Xia W*, Gao WQ*. Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex. Cell Death Differ.2019; 26:2479-2492.

12.    Lu T, Li Z, Yang Y, Ji W, Yu Y, Niu X, Zeng Q, Xia W*, Lu S*. The Hippo/YAP1 pathway interacts with FGFR1 signaling to maintain stemness in lung cancer. Cancer Lett. 2018; 423:36-46.

13.    Wang K, Ji W, Yu Y, Li Z, Niu X, Xia W*, Lu S*. FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer. Oncogene. 2018; 37:5340-5354.

14.    Shao J, Yang X, Liu T, Zhang T, Xie QR, Xia W*. Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal cell death. Protein Cell. 2016, 7:281-290. 

15.    Chen Y, Gu H*, Zhang DS, Li F, Liu T, Xia W*.Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier. Biomaterials. 2014;35:10058-10069.

16.    Xie QR, Liu Y, Shao J, Yang J, Liu T, Zhang T, Wang B, Mruk DD, Silvestrini B, Cheng CY, Xia W*. Male contraceptive Adjudin is a potential anti-cancer drug.  Biochem Pharmacol 2013; 85:345-355.