王富
1. 超分辨熒光與光譜成像
2. 多模態光學診療
1.“雙光子-受激發射損耗(STED)復合顯微鏡”,科技部重點研發專項 “數字診療裝備研發”,課題負責人,441萬🥷🏿。
2. “基於單一激光器的可調雙色及雙光子超分辨顯微鏡”,中科院科研裝備研製項目,項目負責人😂,180萬🏈🦹♂️。
3.“實時原位超分辨光學成像關鍵問題研究”, 科技部重點研發專項“工程科學與綜合交叉”🏋🏻♀️,子課題負責人,76萬。
4. “基於功能納米材料的食品中農獸藥殘留物脫除技術研究”, 科技部重點研發專項 “食品安全關鍵技術研發”,子課題負責人,60萬。
5. 國家自然科學基金委重大科研儀器研製項目,課題負責人,150萬。
6. 國家自然科學基金委青年🟪、面上項目💌,項目負責人。
近五年代表性論文:
(1) Gao, B.; Gao, L.; Wang, J.; Huang, X.; Ge, W.; Li, S.; Wang, F. NIR-II Light Field Microscopy for Through-Skull Hemodynamic Volumetric Imaging in Awake Mice. Laser & Photonics Reviews 2025, 2401685.
(2) Ge, W.; Huang, S.; Huang, X.; Gao, B.; Shen, Z.; Zhuang, X.; Wang, F. Synchronous Passivation Boosts the NIR-II Luminescence Efficiency of Ag2S Nanocrystals for Effective Deep Tissue Lymphatic Mapping. ACS Nano 2025, 19 (6), 6601–6612.
(3) Li, S.; Ge, W.; Huang, X.; Du, H.; Wang, F. Synergistic Intramolecular Charge Transfer Promotes Au Nanoclusters with Enhanced NIR-II Photoluminescence. J. Phys. Chem. Lett. 2025, 16 (5), 1221–1228.
( 4) Huang, X.; Yang, F.; Gao, B,; Ge, W.; Gao, L.; Wu, J.; Tu, S.; Wang, F. Free Carrier-Enhanced Bi/Bi2S3 Nanoparticles Enable Precise OCT Catheter-Guided Interventional Photothermal Therapy for Colorectal Cancer. Acta Biomaterialia. 2025.
(5) Huang, X.; Ge, W.; Li, S.; Huang, R.; Wang, F. Transferrin-Based Bismuth Nanoparticles for Radiotherapy with Immunomodulation Against Orthotopic Glioma. Advanced Healthcare Materials 2025, 14 (7), 2404144.
(6) Huang, X.; Gao, L,; Ge, W.; Li, S.; Liu, Y.; Fan, X.; Tu, S.; Wang, F. An Ultrasound-Activated Piezoelectric Sonosensitizer Enhances Mitochondrial Depolarization for Effective Treatment of Orthotopic Glioma. Acta Biomaterialia 2024, 190, 435–446.
(7) Gao, L.; Gao, B.; Ge, W.; Li, S.; Wang, F. Stimulated Emission Depletion Imaging Reveals Mitochondrial Phenotypic Heterogeneity under Apoptosis Stimuli across Living Glioma Models. Nano Lett. 2024, 24 (49), 15904–15911.
(8) Gao, L.; Dalapati, R.; Gao, B.; Huang, X.; Zhao, D.; Wang, F.; Zang, L. Mitochondrial STED Imaging and Membrane Potential Monitoring with a Cationic Molecular Probe. Small Methods 2024, 8 (12), 2400525.
(9) Ge, W.; Chen, G.; Huang, X.; Gao, B.; Wang, F. Heteroions Radii Matching Produced Intensely Luminescent Bismuth-Ag2S Nanocrystals for through-Skull NIR-II Imaging of Orthotopic Glioma. Nano Lett. 2024, 24 (15), 4562–4570.
(10) Zhao, D.; Gao, L.; Huang, X.; Chen, G.; Gao, B.; Wang, J.; Gu, M.; Wang, F. Complementary Imaging of Nanoclusters Interacting with Mitochondria via Stimulated Emission Depletion and Scanning Transmission Electron Microscopy. Journal of Hazardous Materials 2024, 465, 133371.
(11) Zhao, D.; Huang, X.; Tian, Y.; Zou, J.; Wang, F.; Chen, X. Fluorescence Imaging-Incorporated Transcriptome Study of Glutathione Depletion-Enhanced Ferroptosis Therapy via Targeting Gold Nanoclusters. ACS Appl. Mater. Interfaces 2023,15, 5, 6385–6396.
(12) Huang, X.; Zha, F.; Zou, J.; Li, Y.; Wang, F.; Chen, X. Photoacoustic Imaging-Guided Synergistic Photothermal/Radiotherapy Using Plasmonic Bi/Bi2O3−x Nanoparticles. Advanced Functional Materials, 2022🧼👗,2113353.
(13) Tian, Y.; Zhao, D.; Huang, X.; Guan, X.; Wang, F.; Wei, X. Extended π-Conjugative Carbon Nitride for Single 1064 nm Laser-Activated Photodynamic/Photothermal Synergistic Therapy and Photoacoustic Imaging. ACS Appl. Mater. Interfaces 2022, 14 (6), 7626–7635.
(14) Huang, X.; Zhang, W.; Peng, Y.; Gao, L.; Wang, F.; Wang, L.; Wei, X. A Multifunctional Layered Nickel Silicate Nanogenerator of Synchronous Oxygen Self-Supply and Superoxide Radical Generation for Hypoxic Tumor Therapy. ACS Nano 2022, 16 (1), 974–983.
(15) Peng, Y.; Huang, X.; Wang, F. Near-Infrared Emitting Gold–Silver Nanoclusters with Large Stokes Shifts for Two-Photon in Vivo Imaging. Chem. Commun. 2021, 57 (96), 13012–13015.
郵箱地址👩🏼✈️:wangfu@sjtu.edu.cn
辦公地址🧙⇨:文選醫學樓316